top of page

Kristen Dellinger, PI

Dr. Kristen Dellinger is an Assistant Professor in the Department of Nanoengineering at North Carolina Agricultural and Technical State University (NC A&T) and founder of the NanoBio Innovation Lab. She earned a B.Sc. and an M.Sc. in Chemical Engineering from Queen’s University and a Ph.D. in Biomedical Engineering from McGill University and has authored over 25 peer-reviewed scientific publications, including ACS Nano and Advanced Functional Materials. Currently, Dr. Dellinger's laboratory focuses on designing and evaluating biosensors for early disease detection, including Alzheimer’s disease, exploring extracellular vesicles for disease treatment and diagnosis, and engineering functionalized nanoparticles and 2D platforms for integrated optical sensors in biomedical and environmental applications. Her work has been funded by the National Science Foundation, the National Institutes of Health, the Department of Defense, and NC Innovation. 

EVs_edited_edited.png

Education

P.h.D. in Biomedical Engineering

McGill University

Montreal, Quebec, Canada

"Investigation of the anti-inflammatory properties of 17β-estradiol through the development of nanomaterials for cardiovascular drug delivery and diagnostic applications"

Supervisor: Dr. Maryam Tabrizian

Co-supervisor Dr. Jean Francois Tanguay

M.Sc. in Chemical Engineering

Queen's University

Kingston, Ontario, Canada

"Alginate microparticles produced by spray-drying for oral insulin delivery"

Supervisor: Dr. Ronald Neufeld

B.Sc. in Chemical Engineering

Queen's University 

Kingston, Ontario, Canada

Concentration in Biochemical Engineering

Publications

  1. Ebrahimi F, Kumari A, Al Abdullah S, Vivero-Escoto JL, Dellinger K*. (2025) Surface Functionalization of Citrate-Stabilized Gold Nanoparticles with Various Disease-Specific Aptamers: RSM-Based Optimization for Multifactorial Disease Biomarker Detection. ACS Sensors.

  2. Ebrahimi F, Kumari A, Ghadami S, Al Abdullah S, Dellinger K*. (2024) The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead. Advanced Biology.

  3. Ebrahimi F, Kumari A, Dellinger K*. (2024) Integration of Nanoengineering with Artificial Intelligence and Machine Learning in Surface-Enhanced Raman Spectroscopy (SERS) for the Development of Advanced Biosensing Platforms. Advanced Sensor Research.

  4. Ibrahim AA, Sa'ed M,  Al Abdullah S, Dellinger K, Obare O, Pathiraja G. (2024) Magnetic Zinc Ferrite Nanostructures: Recent Advancements for Environmental and Biomedical Applications. Journal of Alloys and Compounds Communications. DOI: https://doi.org/10.1016/j.jacomc.2024.100038

  5. Bahadorani M, Nasiri M, Dellinger K, Aravamudhan S, Zadegan R. (2024) Engineering Exosomes for Therapeutic Applications: Decoding Biogenesis, Content Modification, and Cargo Loading Strategies. International Journal of Nanomedicine. 7137-7164.

  6. Al Abdullah S, Cocklereece I, Dellinger K*. (2024) Unlocking the Potential of Circulating Small Extracellular Vesicles in Neurodegenerative Disease Through Targeted Biomarkers and Advancements in Biosensing. Exploration of BioMat-X. 1 (2), 100-123. DOI: https://doi.org/10.37349/ebmx.2024.00008

  7. Burton K, Ghadami S, Dellinger K, Wang B, Dong M. (2024) Screening Peptide-Binding Partners for GenX via Phage Display. International Journal of Molecular Sciences. 25(5), 2686. DOI: https://doi.org/10.3390/ijms25052686

  8. Zablon F, Desai P, Dellinger K*, Aravamudhan S*. (2024) Cellular and Exosomal microRNAs: Emerging Clinical Relevance as Targets for Early Breast Cancer Diagnosis and Potential Prognostic Markers. Advanced Biology. 8(4), 2300532. DOI: https://doi.org/10.1002/adbi.202300532

  9. Nasiri, Bahadorani M, Dellinger K, Aravamudhan S, Vivero-Escoto JL, Zadegan R. (2024) Improving DNA Nanostructure Stability: A Review of the Biomedical Applications and Approaches. International Journal of Biological Macromolecules. 129495. DOI: https://doi.org/10.1016/j.ijbiomac.2024.129495

  10. Adesoye S, Al Abdullah S, Kumari A, Pathiraja G, Nowlin K, Dellinger K*. (2023) Au-Coated ZnO Surface-Enhanced Raman Scattering (SERS) Substrates: Synthesis, Characterization, and Applications in Exosome Detection. chemosensors. 11(11), 554; DOI: https://doi.org/10.3390/chemosensors11110554

  11. Ghadami S, Dellinger K*. (2023) The Lipid Composition of Extracellular Vesicles: Applications in Diagnostics and Therapeutic Delivery. Frontiers in Molecular Biosciences – Molecular Diagnostics and Therapeutics. DOI: https://doi.org/10.3389/fmolb.2023.1198044

  12. Al Abdullah S, Najm L, Ladouceur L, Ebrahimi F, Shakeri A, Al-Jabouri N, Didar T*, Dellinger K*. (2023) Functional Nanomaterials for the Diagnosis of Alzheimer’s Disease; Recent Progress and Future Perspectives. Advanced Functional Materials. DOI: https://doi.org/10.1002/adfm.202302673

  13. Adesoye S, Al Abdullah S, Nowlin K, Dellinger K*. (2022) Mg-Doped ZnO Nanoparticles with Tunable Band Gaps for Surface-Enhanced Raman Scattering (SERS)-Based Sensing. nanomaterials. DOI: https://doi.org/10.3390/nano12203564

  14. Adesoye S, Dellinger K*. ZnO and TiO2 nanostructures for surface-enhanced Raman scattering-based biosensing: A review. (2022) Sensing and Bio-Sensing Research. DOI: https://doi.org/10.1016/j.sbsr.2022.100499

  15. Fereydouni M, Ahani E, Motaghed M, Metcalfe DD, Yen Y, Kafri T, Bhatt AP, Dellinger K, Kepley C. (2022) Human tumor targeted cytotoxic mast cells for cancer immunotherapy. Frontiers in Oncology. DOI: https://doi.org/10.3389/fonc.2022.871390

  16. Fereydouni M, Motaghed M, Ahani E, Kafri T, Desai P, Dellinger K, Metcalfe DD, Kepley C. (2022) Harnessing the Anti-Tumor Mediators in Mast Cells as a New Strategy for Adoptive Cell Transfer for Cancer. Frontiers in Oncology. DOI: https://doi.org/10.3389/fonc.2022.830199

  17. Khan S, Burciu B, Filipe C, Li Y, Dellinger K*, Didar T*. (2021). DNAzyme-based biosensors: immobilization strategies, applications, and future prospective. ACS Nano. DOI: https://doi.org/10.1021/acsnano.1c04327

  18. Tinker-Kulberg RT, Dellinger A, Gentit LC, Fluech B, Wilder CA, Spratling IL, Robertson R, Goddard MK, Brady TE, Dellinger K*. (2020). Evaluation of indoor and outdoor aquaculture systems as alternatives to harvesting hemolymph from random wild capture of horseshoe crabs. Frontiers in Marine Science. DOI: https://doi.org/10.3389/fmars.2020.568628

  19. Tinker-Kulberg RT, Dellinger A, Brady TE, Robertson R, Goddard MK, Bowzer, J, Abood SK, Kepley CL, Dellinger K*. (2020). Effects of diet on the biochemical properties of amebocyte lysates in Limulus polyphemus in an aquaculture setting. Frontiers in Marine Science. DOI: https://doi.org/10.3389/fmars.2020.541604

  20. Tinker-Kulberg RT, Dellinger K, Brady TE, Robertson R, Levy JH, Abood SK, Laduca F, Kepley CL, Dellinger A. et al. (2020). Horseshoe crab aquaculture as a sustainable endotoxin testing source. Frontiers in Marine Science, 7, 153. DOI: https://doi.org/10.3389/fmars.2020.00153

  21. Brady TE, Abood SK, Tinker-Kulberg RT, Dellinger K, ... & Dellinger AL. (2019). Olfactory mediation of canine gastrointestinal neurobiology. Journal of Animal Health and Behavioral Science, 3, 1. https://www.omicsonline.org/peer-reviewed/olfactory-mediation-of-canine-gastrointestinal-neurobiology-108794.html

  22. Krisfalusi-Gannon J, Ali W, Dellinger K, Robertson L, Brady TE, Goddard MK, ... & Dellinger AL (2018). The role of horseshoe crabs in the biomedical industry and recent trends impacting species sustainability. Frontiers in Marine Science, 5, 185. DOI: doi.org/10.3389/FMARS.2018.00185

  23. Bowey-Dellinger K, Segarra V et al. (2017) An introductory biology laboratory designed to introduce mammalian cell culture and cell viability techniques in the undergraduate laboratory. J Microbiol Biol Educ. 18(2):1-7. DOI: doi.org/10.1128/jmbe.v18i2.1264

  24. Bowey K, Tabrizian M et al. (2014) Microwave-assisted surface-enhanced Raman scattering nanoprobes for vascular disease biomarker detection and mapping. Colloids Surf. B. 122 (1): 617 – 622.  DOI: doi.org/10.1016/j.colsurfb.2014.07.040

  25. Bowey K, Tanguay JF, Tabrizian M. (2013) 1,2-Dioleoyl-sn-glycero-3-phosphocholine–based liposomal nanoparticles as an effective delivery platform for 17β-estradiol. European Journal of Pharmaceutics and Biopharmaceutics. 86 (3): 369 – 375. DOI: doi.org/10.1016/j.ejpb.2013.10.006

  26. Fatanat Didar T, Bowey K, Guillermina A, Tabrizian M. (2013) A miniaturized platform for rapid, label-free and simultaneous separation, patterning and in vitro culture of primary and rare cells. Advanced Healthcare Materials. 3 (2): 253 – 260. DOI: doi.org/10.1002/adhm.201300099

  27. Bowey K, Tanguay JF, Tabrizian M. (2012) Liposome technology for cardiovascular disease treatment and diagnosis. Expert Opinion on Drug Delivery. 9 (2): 249 – 265. DOI: doi.org/10.1517/17425247.2012.647908

  28. Bowey K, Swift B, Flynn LE, Neufeld RJ. (2012) Characterization of biologically active insulin-loaded alginate microparticles by spray drying. Drug Development and Industrial Pharmacy. 39 (3): 456 – 465. DOI: doi.org/10.3109/03639045.2012.662985

  29. Bowey K, Neufeld R. (2012) Systemic and mucosal delivery of drugs within polymeric microparticles produced by spray drying – Review Article. Biodrugs. 24 (6): 359 – 377. DOI: doi.org/10.2165/11539070-000000000-00000  

Call 

336-285-2868

Email 

kdellinger@ncat.edu

Follow

  • LinkedIn
  • Instagram
bottom of page